Efficacy and Safety of Low-to-Moderate Dose Oral Corticosteroid Treatment in Ocular Myasthenia Gravis
| Autor: | Yoon Gon Lee, Ungsoo Samuel Kim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male myalgia medicine.drug_class Ocular myasthenia Administration Oral Methylprednisolone 03 medical and health sciences 0302 clinical medicine Ptosis Myasthenia Gravis Diplopia Blepharoptosis Humans Medicine Strabismus Glucocorticoids Aged business.industry General Medicine Middle Aged medicine.disease Myasthenia gravis Ophthalmology Treatment Outcome Anesthesia Pediatrics Perinatology and Child Health 030221 ophthalmology & optometry Corticosteroid Female medicine.symptom business 030217 neurology & neurosurgery Strabismus surgery medicine.drug |
| Zdroj: | Journal of Pediatric Ophthalmology & Strabismus. 55:339-342 |
| ISSN: | 1938-2405 0191-3913 |
| Popis: | Purpose: To evaluate the response to corticosteroid therapy as a primary treatment for ocular myasthenia gravis. Methods: Patients diagnosed as having ocular myasthenia gravis by an acetylcholine receptor binding antibody test between January 2011 and September 2015 were included in the study and started receiving treatment with a corticosteroid. Patients with a blowout fracture, hyperthyroidism, diabetes mellitus, hypertension, cardiovascular disease, or history of strabismus surgery were excluded. Disappearance of diplopia and ptosis were considered a response to treatment. Results: Methylprednisolone therapy was administered to 29 patients (19 men and 10 women; average age: 49 ± 16.5 years) as an initial treatment. A total of 6 patients were lost to follow-up. Twenty-three of 29 patients (82.6%) were regarded as having presented a response to treatment. The average treatment duration was 3 weeks for patients responding to primary treatment. Eight patients complained of adverse effects from steroid therapy such as heartburn, insomnia, weight gain, and myalgia. Conclusions: A corticosteroid could be considered as an initial treatment for patients diagnosed as having ocular myasthenia gravis by an acetylcholine receptor binding antibody test. [ J Pediatr Ophthalmol Strabismus . 2018;55(5):339-342.] |
| Databáze: | OpenAIRE |
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