Are extended and continuous infusions of time dependent antibiotics used in the management of sepsis in england today?
| Autor: | JC Roberts, JA Dunning |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.drug_class Antibiotics Phases of clinical research Serum concentration Critical Care and Intensive Care Medicine medicine.disease Sepsis Minimum inhibitory concentration Pharmacokinetics Intensive care Poster Presentation Medicine business Intensive care medicine Cause of death |
| Zdroj: | Intensive Care Medicine Experimental |
| ISSN: | 2197-425X |
| DOI: | 10.1186/2197-425x-3-s1-a396 |
| Popis: | Sepsis remains a leading cause of death in intensive care units. Administration of appropriate antibiotics within the first hour of diagnosis has been found to be the most effective intervention associated with a reduction in mortality [[1]]. Currently pharmacokinetic profiles of antibiotics are determined by phase II clinical trials that are undertaken by fit and well volunteers however many studies have shown that this data cannot be extrapolated accurately to the critically unwell [[2]]. Some have proposed that continuous and extended infusions of time dependent antibiotics maximise efficacy by increasing the time in which serum concentration is maintained above the minimum inhibitory concentration therefore improving clinical outcomes. |
| Databáze: | OpenAIRE |
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