Fine-Needle Aspiration Cytology of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma Is Cytomorphologically Distinct From the Invasive Counterpart
| Autor: | Howard H. Wu, Ashley A. Ibrahim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty endocrine system diseases Lymphovascular invasion Cytodiagnosis Biopsy Fine-Needle Noninvasive follicular thyroid neoplasm with papillary-like nuclear features Thyroid Gland 030209 endocrinology & metabolism Carcinoma Papillary Follicular medicine.disease_cause Surgical pathology Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Humans Medicine Neoplasm Invasiveness Thyroid Neoplasms Thyroid neoplasm Aged Aged 80 and over medicine.diagnostic_test business.industry Thyroid General Medicine Middle Aged Fine-needle aspiration medicine.anatomical_structure Cytopathology 030220 oncology & carcinogenesis Female Radiology business |
| Zdroj: | American Journal of Clinical Pathology. 146:373-377 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/aqw126 |
| Popis: | Objectives: To review a series of noninvasive encapsulated follicular variant of papillary thyroid carcinomas (FVPTCs) in an attempt to further define the role of cytopathology in the diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features and invasive FVPTC. Methods: Surgical pathology cases diagnosed as FVPTC with correlating thyroid fine-needle aspiration (FNA) were identified and divided into two FVPTC groups: noninvasive and invasive. Cytologic diagnoses were compared between them. Results: We identified 23 cases that met the criteria for noninvasive FVPTC and 27 cases that were typical infiltrative FVPTC (n = 16) or encapsulated FVPTC with either capsular and/or lymphovascular invasion (n = 11). Of the noninvasive FVPTC cases, there were four benign lesions, 14 follicular lesions of undetermined significance (FLUS), four follicular neoplasms (FNs), one suspicious case, and no papillary thyroid carcinomas (PTCs). In the invasive FVPTC group, there were no benign cases, four FLUS, three FNs, 12 suspicious cases, and eight PTCs. Conclusions: There is a distinction in the cytologic diagnosis between noninvasive and invasive FVPTC. The invasive subtype was diagnosed by FNA as suspicious for PTC or PTC in nearly 75% of cases, while only one (4%) case for the noninvasive subtype was diagnosed as suspicious for PTC ( P |
| Databáze: | OpenAIRE |
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