Prognostic factors and treatment modalities in uterine sarcoma
| Autor: | Adnan Ezzat, G. Mohamed, Walid A. Mourad, N. Al Bareedy, G. El Husseiny, J. Subhi, Mohamed Shoukri |
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| Rok vydání: | 2002 |
| Předmět: |
Leiomyosarcoma
Adult Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Ovariectomy Antineoplastic Agents Hysterectomy Carcinosarcoma Medicine Humans Stage (cooking) Uterine Neoplasm Aged Endometrial stromal sarcoma Uterine sarcoma business.industry Radiotherapy Dosage Sarcoma Middle Aged medicine.disease Prognosis Combined Modality Therapy Survival Analysis Surgery Oncology Multivariate Analysis Uterine Neoplasms Lymph Node Excision Female business |
| Zdroj: | American journal of clinical oncology. 25(3) |
| ISSN: | 0277-3732 |
| Popis: | The aim of this study was to identify the impact of various prognostic factors in the management of uterine sarcoma. Fifty-nine patients with uterine sarcoma were treated at King Faisal Specialist Hospital and Research Center between 1980 and 1997. Forty-three patients (73%) were treated by total abdominal hysterectomy and bilateral salpingo-oophorectomy, 7 (12%) total abdominal hysterectomy and bilateral salpingo-oophorectomy with sampling of pelvic lymph nodes, and 9 (15%) had biopsy only. Nine patients received adjuvant treatment; five had radiation therapy (XRT), two had chemotherapy, one had combined XRT and chemotherapy, and one received hormonal treatment. Leiomyosarcoma cases accounted for 42% of all the uterine sarcomas, carcinosarcoma cases for 34%, and endometrial stromal sarcoma (ESS) for 24%. Fifty (85%) patients had pathologic grade II and III tumor, with only 9 patients grade I. Twenty-seven patients (46%) were classified surgically as stage I, 7 (12%) as stage II, 17 (29%) as stage III, and 8 (13%) had stage IV tumor. Recurrences developed in 34 patients (71%). The 5- and 10-year overall actuarial survival for all patients was 42%, and the corresponding relapse-free survivals for those who achieved complete response after primary treatment (48 patients) were 27% and 20%. On the univariate analysis, grade I tumors (p = 0.04), ESS (p = 0.02), nonmetastatic stage (p = 0.05), and negative peritoneal cytology (p = 0.04) were associated with better overall survival. Factors associated |
| Databáze: | OpenAIRE |
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