Acrylamide applied during pregnancy causes the neurotoxic effect by lowering BDNF levels in the fetal brain
| Autor: | Mehmet Erman Erdemli, Eyup Altinoz, Harika Gozukara Bag, Sezin Demirtas, Birgul Yigitcan, Yusuf Turkoz, M. Arif Aladag |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Toxicology medicine.disease_cause Superoxide dismutase Necrosis 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Developmental Neuroscience Pregnancy Internal medicine Animals Medicine chemistry.chemical_classification Acrylamide Fetus biology business.industry Brain-Derived Neurotrophic Factor Glutathione peroxidase Brain Glutathione Malondialdehyde Acetylcysteine Rats Oxidative Stress 030104 developmental biology Endocrinology chemistry Toxicity biology.protein Female business Intracranial Hemorrhages 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Neurotoxicology and Teratology. 67:37-43 |
| ISSN: | 0892-0362 |
| DOI: | 10.1016/j.ntt.2018.03.005 |
| Popis: | Objectives The aim of this study is to elucidate the possible mechanism of neurotoxic effect of acrylamide (AA) applied during pregnancy on fetal brain development and to show the effect of N-acetylcysteine (NAC) on AA toxicity. Materials and methods Four groups were formed with 9 pregnant rats each as control (C), acrylamide (AA), N-acetylcysteine (NAC), acrylamide plus N-acetylcysteine (AA plus NAC) groups. Caesarian section was implemented on the 20th day of pregnancy. Malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and Brain-derived neurotrophic factor (BDNF) levels were analyzed and histopathologic examinations were performed in brain tissues of the fetuses. Results Our data indicated that AA caused necrotic death and hemorrhagic damages in fetal brain tissue with decreasing BNDF levels and increasing oxidative stress. N-acetylcysteine prevented the toxic effects of its on fetal brain (p Conclusion Our study indicated that acrylamide has toxic effects in the fetal brain and N-acetylcysteine prevents its toxic effect. |
| Databáze: | OpenAIRE |
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