Frequency of differential placental transfer to twins of maternal antiretroviral medications
Autor: | Minh Tam Le, Gilles Peytavin, Dominique Luton, Margaux Louchet, Luc Rigonnot, Laurent Mandelbrot, Isabelle Matheron, Hélène Didelot, Lionel Carbillon, Agnès Bourgeois-Moine |
---|---|
Přispěvatelé: | Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Paris (UP), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Hôpital Jean Verdier [AP-HP], Centre Hospitalier Intercommunal Villeneuve-Saint-Georges (CHIV), Centre Hospitalier Sud Francilien, CH Evry-Corbeil, CCSD, Accord Elsevier, Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Placenta
[SDV]Life Sciences [q-bio] Twins Physiology HIV Infections Emtricitabine Placental transfer Cohort Studies 03 medical and health sciences Zidovudine 0302 clinical medicine Pregnancy medicine Twins Dizygotic Humans 030212 general & internal medicine Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Lamivudine virus diseases Antiretrovirals HIV Lopinavir Twins Monozygotic medicine.disease 3. Good health Atazanavir [SDV] Life Sciences [q-bio] Reproductive Medicine Pharmaceutical Preparations Ritonavir Female business Saquinavir medicine.drug |
Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology European Journal of Obstetrics & Gynecology and Reproductive Biology, Elsevier, 2021, 256, pp.405-411. ⟨10.1016/j.ejogrb.2020.11.004⟩ European Journal of Obstetrics & Gynecology and Reproductive Biology, 2021, 256, pp.405-411. ⟨10.1016/j.ejogrb.2020.11.004⟩ |
ISSN: | 0301-2115 |
Popis: | Background Placental passage of drugs in twins is poorly understood, and is unknown regarding antiretrovirals (ARVs). In the event of large differences in the exposure of 2 twins to the same maternal therapy, this could have a clinical impact in terms of prevention of perinatal HIV transmission or adverse effects. Objective To describe the frequency of differential transplacental passage of antiretrovirals between twins. Study design The study was performed retrospectively, on data from women included in a multicenter perinatal HIV cohort study. All twin pairs for which the mother received antiretroviral therapy and for which drug concentrations in both of the umbilical cords after cord clamping at delivery were studied. We considered that a difference in concentrations of more than 50 % between twins was a substantial difference (ratios below 0.67 or above 1.50). Results We analyzed 29 twin pairs, 27 dichorionic and 2 monochorionic diamniotic. Cord blood concentrations differed between the 2 twins by more than 50 % for at least one ARV in 9 twin pairs, 8 dichorionic and 1 monochorionic. Discordant concentrations were observed in one or more cases for several nucleoside reverse transcriptase inhibitors (tenofovir, emtricitabine, lamivudine, zidovudine) and protease inhibitors (atazanavir, lopinavir, saquinavir et ritonavir); within individual twin pairs placental transfer was discordant for one or more ARVs, but identical for others. Conclusion Concentrations differed in nearly one third of twin pairs. This may be due to interindividual genetic variability of placental transporters between dizygotic twins as well as physiological differences between twins. |
Databáze: | OpenAIRE |
Externí odkaz: |