Incidence of Recurrent High-Grade Anal Dysplasia in HIV-1-Infected Men and Women Following Infrared Coagulation Ablation: A Retrospective Cohort Study
| Autor: | Corral, Javier, Parés, David, García-Cuyás, Francesc, Revollo, Boris, Chamorro, Ana, Lecumberri, Carla, Tarrats, Antoni, Castella, Eva, Piñol, Marta, Clotet Sala, Bonaventura, Videla, Sebastià, Sirera, Guillem, Universitat Autònoma de Barcelona |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Human immunodeficiency virus (HIV) Diseases of the anus lcsh:Medicine medicine.disease_cause Infrared coagulation Article 03 medical and health sciences anal intraepithelial neoplasia 0302 clinical medicine Internal medicine Cytology medicine Immunology and Allergy Cumulative incidence Malalties de l'anus 030212 general & internal medicine Molecular Biology high-resolution anoscopy General Immunology and Microbiology business.industry Incidence (epidemiology) lcsh:R HPV infection Anal dysplasia Retrospective cohort study medicine.disease HIV infection infrared coagulation Infectious Diseases anal dysplasia 030211 gastroenterology & hepatology Infeccions per VIH business HIV infections |
| Zdroj: | Pathogens r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Dipòsit Digital de la UB Universidad de Barcelona Pathogens, Vol 10, Iss 208, p 208 (2021) Volume 10 Issue 2 |
| ISSN: | 2076-0817 |
| Popis: | This single-center, retrospective cohort study sought to estimate the cumulative incidence in HIV-1-infected patients of biopsy-proven high-grade anal intraepithelial neoplasia (HGAIN) recurrence after infrared coagulation (IRC) treatment. The study was based on data from a prospectively compiled database of 665 HIV-1-infected outpatients who attended a hospital Clinical Proctology/HIV Unit between January 2012 and December 2015. Patient records were checked to see which ones had received IRC treatment but later experienced a recurrence of HGAIN. Cytology samples were also checked for the presence of human papilloma virus (HPV). A total of 81 of the 665 patients (12%, 95%CI: 10–15%), of whom 65 were men and 16 women, were diagnosed with HGAIN and again treated with IRC. Of these 81, 20 (25%) experienced recurrent HGAIN, this incidence being true of both men (16/65, 95%CI: 19–57%) and women (4/16, 95%CI: 10–50%). The median time to recurrence was 6 (2–19) months overall, 6 (2–19) months in men, and 4 (2–6) months in women. HPV infection was detected in all patients except two, with HPV-16 being the most common genotype. This rate of incidence of recurrent HGAIN following IRC treatment is consistent with other reports and highlights the importance of continued post-treatment surveillance, particularly in the first year. |
| Databáze: | OpenAIRE |
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