Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era
| Autor: | Djaouida Bengoufa, L. Iordache, Alfred Mahr, Agathe Rami, Nesrine Day, Caroline Lascoux-Combe, Pierre-Olivier Sellier, Maguy Parrinello, Olivier Taulera, Jean-Michel Molina |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty HAART Anti-nuclear antibody autoantibodies Observational Study HIV Infections antinuclear antibodies Gastroenterology Immunoglobulin G 03 medical and health sciences Antigen Proteinase 3 immune system diseases Internal medicine Antiretroviral Therapy Highly Active medicine Humans Anti-neutrophil cytoplasmic antibody biology business.industry Hypergammaglobulinemia Autoantibody HIV General Medicine Middle Aged medicine.disease 3. Good health 030104 developmental biology Cross-Sectional Studies biology.protein ANCAs Female Antibody business hypergammaglobulinemia Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Nonorgan-specific autoantibodies (AAbs) are used for diagnosing autoimmune diseases but can also be detected in other conditions. We carried out a cross-sectional study with the aim to screen HIV1-infected patients in the era of highly active antiretroviral therapy (HAART) for AAbs and to analyze the association of their presence with hypergammaglobulinemia and immunovirological status. Blood samples from HIV1-infected patients without major concomitant illnesses followed in 2 hospitals in Paris, France were tested for immunovirological status, serum immunoglobulin G (IgG) level, antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), anti-extractable nuclear antigens (anti-ENAs), anticardiolipin (aCL), anti-β2glycoprotein1 (anti-β2GP1), and antineutrophil cytoplasmic antibodies (ANCAs). Clinically relevant AAbs were defined as ANAs with titers ≥1:160, anti-dsDNA or anti-ENA antibodies; aCL or anti-β2GP1 antibodies with a level ≥40 U/ml; and ANCAs reacting with proteinase 3 or myeloperoxidase. We included 92 patients (mean age 47 years, men 55%, sub-Saharan African background 55%, HAART 85%, mean CD4 lymphocyte count 611/mm3, viral load |
| Databáze: | OpenAIRE |
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