Site-selective C–H activation and regiospecific annulation using propargylic carbonates

Autor:	Sara Cembellín, Frank Glorius, Shobhan Mondal, Qingquan Lu, Steffen Greßies
Rok vydání:	2019
Předmět:	chemistry.chemical_classification Annulation Ketone Nitrile 010405 organic chemistry Chemistry Carboxylic acid General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Sulfonamide chemistry.chemical_compound Amide Moiety Molecule
Zdroj:	Chemical Science
ISSN:	2041-6539 2041-6520
DOI:	10.1039/c9sc01703h
Popis:	Herein we describe an unprecedented RuII-catalyzed site-selective and regiospecific annulation of benzoic acids with propargylic carbonates. The weakly coordinating carboxylic acid moiety outperformed other typically used directing groups in C–H activation, including ketone, nitrile, sulfonamide, amide and strongly coordinating nitrogen heterocycles. Herein we describe an unprecedented RuII-catalyzed site-selective and regiospecific annulation of benzoic acids with propargylic carbonates. The weakly coordinating carboxylic acid moiety outperformed other typically used directing groups in C–H activation, including ketone, nitrile, sulfonamide, amide and strongly coordinating nitrogen heterocycles. This is an important step towards the application of C–H activation reactions in complex (functional) real-world molecules.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474e0cf5c9df97f57775fba35c59f2a4 https://doi.org/10.1039/c9sc01703h Zobrazit plný text záznamu