The treatment of colorectal hepatic metastases by continuous local infusion of interleukin-2
| Autor: | Prf Bell, P. S. Veitch, Em Watkin, Ss Ubhi, J Hollingworth, T. Horsburgh |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Interleukin 2
Oncology Cancer Research medicine.medical_specialty Oncogene Colorectal cancer business.industry Cancer hemic and immune systems chemical and pharmacologic phenomena medicine.disease Molecular medicine Gastroenterology Regimen Catheter Internal medicine Toxicity medicine business medicine.drug |
| Zdroj: | International journal of oncology. 1(5) |
| ISSN: | 1019-6439 |
| Popis: | Patients with hepatic metastases from colorectal cancer appear to be resistant to most forms of therapy. Recent reports suggest synergism between systemically administered recombinant interleukin-2 (rIL-2) and 5-fluorouracil (5-FU) with responses documented in the treatment of advanced colonic tumours albeit with significant toxicity. Local continuous infusion of rIL-2 into selected sites may reduce toxicity and increase efficacy. We have assessed the feasibility of continuously infusing rIL-2 into the region of a hepatic metastasis in 3 patients via a catheter placed within the liver under ultrasound guidance in a regimen including systemic rIL-2 and 5FU. |
| Databáze: | OpenAIRE |
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