RSK Isoforms in Acute Myeloid Leukemia
| Autor: | Jesus Omar Gomez, Kathleen M. Sakamoto, Kailen Mark, Minyoung Youn |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Gene isoform
Chemokine hematological malignancy Cell growth Kinase QH301-705.5 Medicine (miscellaneous) Myeloid leukemia Review RSK inhibitors Biology medicine.disease General Biochemistry Genetics and Molecular Biology Serine Leukemia AML Cancer research medicine biology.protein Phosphorylation cancer Biology (General) RSK isoforms |
| Zdroj: | Biomedicines Biomedicines, Vol 9, Iss 726, p 726 (2021) |
| ISSN: | 2227-9059 |
| Popis: | Ribosomal S6 Kinases (RSKs) are a group of serine/threonine kinases that function downstream of the Ras/Raf/MEK/ERK signaling pathway. Four RSK isoforms are directly activated by ERK1/2 in response to extracellular stimuli including growth factors, hormones, and chemokines. RSKs phosphorylate many cytosolic and nuclear targets resulting in the regulation of diverse cellular processes such as cell proliferation, survival, and motility. In hematological malignancies such as acute myeloid leukemia (AML), RSK isoforms are highly expressed and aberrantly activated resulting in poor outcomes and resistance to chemotherapy. Therefore, understanding RSK function in leukemia could lead to promising therapeutic strategies. This review summarizes the current information on human RSK isoforms and discusses their potential roles in the pathogenesis of AML and mechanism of pharmacological inhibitors. |
| Databáze: | OpenAIRE |
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