Antithyroid and antiadrenal autoantibodies in antiglomerular basement membrane disease, thin basement membrane disease and Alport syndrome
| Autor: | Peter J. Thurlow, Judy Savige, P. Branley, Paul J Neeson, Stephen R. Holdsworth |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Thin basement membrane disease endocrine system Adolescent endocrine system diseases Anti-Glomerular Basement Membrane Disease Thyroid Gland Nephritis Hereditary urologic and male genital diseases Thyroglobulin Basement Membrane Pathology and Forensic Medicine Microsomes Adrenal Glands medicine Goodpasture's syndrome Humans Alport syndrome Autoantibodies Hematuria Basement membrane business.industry Glomerular basement membrane Glomerulonephritis Middle Aged medicine.disease Anti-thyroid autoantibodies medicine.anatomical_structure Immunology Female business Biomarkers |
| Zdroj: | Pathology. 30:30-33 |
| ISSN: | 0031-3025 |
| DOI: | 10.1080/00313029800169635 |
| Popis: | The basement membranes of the glomerulus, thyroid and adrenal all contain the Goodpasture antigen, the target of autoantibodies in antiglomerular basement membrane (GBM) disease. Antithyroid antibodies can be associated with antiGBM disease, and there have been occasional reports of antithyroid antibodies in Alport syndrome, an inherited kidney disease where the GBM lacks the Goodpasture antigen. The aim of this study was to determine how often antithyroid and antiadrenal autoantibodies occurred in antiGBM disease, Alport syndrome and a related condition, thin basement membrane disease (TBMD). Sera from patients with antiGBM disease (n = 19), Alport syndrome (n = 5) or TBMD (n = 13) were tested for antithyroglobulin, antithyroid microsomal and antiadrenal antibodies. Five of the patients with antiGBM disease (5/19, 26%, P NS) had antimicrosomal, and one had antithyroglobulin, antibodies (1/19, 5%, P NS). No patient with Alport syndrome had antithyroid antibodies. One with TBMD (1/13, 8%, P NS) had antithyroglobulin and antimicrosomal antibodies at titres of 1/400 and 1/25,600, respectively. Both patients with antithyroglobulin antibodies had previously been diagnosed with hypothyroidism. No one with antiGBM disease, Alport syndrome or TBMD had antiadrenal antibodies. Antithyroid microsomal antibodies do not occur significantly more often in patients with antiGBM disease than in normals, and antithyroid and antiadrenal antibodies are not associated with Alport syndrome or TBMD. |
| Databáze: | OpenAIRE |
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