Acquired platelet defect associated with gabapentin treatment: a case-report
| Autor: | Tatiana Baglo, Claire Pouplard, Eve-Anne Guéry, Yves Gruel, Jean-Baptiste Valentin, Caroline Vayne |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Platelets 0301 basic medicine Platelet Function Tests Gabapentin business.industry Hemorrhage Hematology General Medicine 030204 cardiovascular system & hematology Peripheral neuropathic pain 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Anesthesia medicine Humans Female Platelet business Structural analog medicine.drug |
| Zdroj: | Platelets. 32:846-849 |
| ISSN: | 1369-1635 0953-7104 |
| Popis: | Gabapentin, a structural analog of gamma-aminobutyric acid, is used to treat peripheral neuropathic pain. Here we report the first case of platelet function disorder associated with gabapentin treatment in a 44-year-old woman without a history of bleeding. She presented with mucocutaneous bleeding approximately 1 month after initiation of gabapentin and platelet function tests showed no aggregation to arachidonic acid and epinephrine, a defective response to ADP and a slightly decreased response to collagen. Gabapentin's imputability was supported by the fact that all platelet functions were normalized 6 days after drug discontinuation, with the simultaneous disappearance of bleedings. |
| Databáze: | OpenAIRE |
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