Effects of horminone on liver mixed function mono-oxygenases and glutathione enzyme activities of Wistar rat
| Autor: | J. Cruz Morais, Fátima Simões, Fátima Candeias, R. Ferreira, José Nascimento |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Glutathione reductase Aspartate transaminase Aniline Hydroxylase 7-Alkoxycoumarin O-Dealkylase Biology Reductase Pharmacology Mixed Function Oxygenases chemistry.chemical_compound Mice Cytochrome P-450 Enzyme System Liver Function Tests Drug Discovery medicine Cytochrome P-450 CYP1A1 Animals Aspartate Aminotransferases Rats Wistar Glutathione Transferase NADPH-Ferrihemoprotein Reductase Unspecific monooxygenase Plants Medicinal Ethylmorphine-N-Demethylase Cytochrome P450 Alanine Transaminase Glutathione Ethylmorphine Rats Cytochromes b5 Glutathione Reductase Biochemistry Alanine transaminase chemistry Liver Enzyme Induction Abietanes biology.protein Diterpenes Injections Intraperitoneal medicine.drug |
| Zdroj: | Journal of ethnopharmacology. 58(1) |
| ISSN: | 0378-8741 |
| Popis: | The present study reports on the effects of horminone on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, on hepatic cytochrome P450 (P450) and cytochrome b5 (cyt b5) contents and on the activities of NADPH-cytochrome P450 reductase (NR), mixed function mono-oxygenases (MFO), glutathione-S-transferase (GST) and glutathione reductase (GR) of Wistar male rat. Horminone is a diterpenoid quinone (7,12-dihydroxyabiet-8,12-diene-11,14-dione) present in several species of the Labiatae family and used as medicinal plants in folk medicine. In this study, horminone was administered by the intraperitoneal route (i.p.) at a concentration of 1 or 10 mg/kg to each group of six mice, using water as a vehicle. On the one hand, results showed that horminone increased serum ALT and AST levels and cyt b5 content and induced the activities of ethylmorphine N-demethylase (EMD). On the other hand, horminone decreased P450 content and inhibited the activities of 7-ethoxyresorufin O-deethylase (ERD), 7-ethoxycoumarin O-deethylase (ECD), aniline 4-hydroxylase (AH) and NR. Based on these results, the possibility of toxic effects occurring after administration of plant extracts containing horminone must be considered. |
| Databáze: | OpenAIRE |
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