Potential Roles for Gamma-Aminobutyric Acid Signaling in Bacterial Communities

Autor:	Arthur Prindle, Sarah J. Quillin, Peter Tran
Rok vydání:	2021
Předmět:	Transplantation biology Gut–brain axis Biomedical Engineering Reviews Medicine (miscellaneous) Bidirectional communication biology.organism_classification Gut microbiome gamma-Aminobutyric acid Cell biology medicine GABAergic Electrical and Electronic Engineering Bacteria medicine.drug
Zdroj:	Bioelectricity
ISSN:	2576-3113 2576-3105
Popis:	It is now established that the gut microbiome influences human neurology and behavior, and vice versa. Distinct mechanisms underlying this bidirectional communication pathway, termed the gut-brain axis, are becoming increasingly uncovered. This review summarizes recent interkingdom signaling research focused on gamma-aminobutyric acid (GABA), a human neurotransmitter and ubiquitous signaling molecule found in bacteria, fungi, plants, invertebrates, and mammals. We detail how GABAergic signaling has been shown to be a crucial component of the gut-brain axis. We further describe how GABA is also being found to mediate interkingdom signaling between algae and invertebrates, plants and invertebrates, and plants and bacteria. Based on these emerging results, we argue that obtaining a complete understanding of GABA-mediated communication in the gut-brain axis will involve deciphering the role of GABA signaling and metabolism within bacterial communities themselves.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4742d4b8544bfaab3ced307c0584e10b https://doi.org/10.1089/bioe.2021.0012 Zobrazit plný text záznamu