Broad and long-lasting immune protection against various Chikungunya genotypes demonstrated by participants in a cross-sectional study in a Cambodian rural community
Autor: | Rithea Leang, Saraden In, Arnaud Tarantola, Sivuth Ong, Veasna Duong, Sowath Ly, Sokthearom Mao, Rekol Huy, Heidi Auerswald, Philippe Dussart, Camille Boussioux, Malen Chan |
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Přispěvatelé: | Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), National Center of Parasitology (CNM), National Malaria Center [Phnom Penh], Institut Pasteur de Nouvelle-Calédonie, This work was funded by the Institut Pasteur du Cambodge. The postdoctoral fellowship of Heidi Auerswald is supported bythe Calmette and Yersin Programme of the Institut Pasteur Department of International Affairs. |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Serotype Adult Immunity Herd Male Rural Population Genotype Epidemiology [SDV]Life Sciences [q-bio] 030231 tropical medicine Immunology Population Biology Cross Reactions medicine.disease_cause Antibodies Viral Microbiology Virus Article Herd immunity Disease Outbreaks 03 medical and health sciences 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Neutralization Tests Virology Drug Discovery medicine Animals Humans Chikungunya education Phylogeny education.field_of_study Risk of infection Outbreak General Medicine Antibodies Neutralizing 3. Good health 030104 developmental biology Infectious Diseases Cross-Sectional Studies Chikungunya Fever Parasitology Female Cambodia Chikungunya virus |
Zdroj: | Emerging Microbes & Infections Emerging microbes & infections Emerging microbes & infections, Earliest : Springer-Nature ; Latest : Taylor & Francis, 2018, 7 (1), pp.13. ⟨10.1038/s41426-017-0010-0⟩ |
ISSN: | 2222-1751 |
Popis: | International audience; Chikungunya virus (CHIKV) is an alphavirus circulating worldwide. Its presence in Asia has been reported since the 1950s, constituting the Asian genotype. Since 2005, strains from the Eastern, Central, and Southern African (ECSA) genotype have caused several outbreaks across Asia. Viruses from the ECSA genotype were also detected in Cambodia in late 2011 and led to an outbreak in a rural community in 2012. A former investigation from 2012 found a higher risk of infection in people younger than 40 years, suggesting a pre-existing herd immunity in the older Cambodian population due to infection with an Asian genotype. In 2016, we collected serum from equivalent numbers of individuals born before 1975 and born after 1980 that were also part of the 2012 study. We analyzed the 154 serum samples from 2016 for neutralization against the Cambodian ECSA isolate and three strains belonging to the Asian genotype. This experiment revealed that 22.5% (18/80) of the younger study participants had no CHIKV antibodies, whereas 5.4% (4/74) of the older population remained naive. Study participants infected during the ECSA outbreak had twofold neutralizing titers against the ECSA and the most ancient Asian genotype virus (Thailand 1958) compared to the other two Asian genotype viruses. The neutralization data also support the older population's exposure to an Asian genotype virus during the 1960s. The observed cross-reactivity confirms that the investigated CHIKV strains belong to a single serotype despite the emergence of novel ECSA genotype viruses and supports the importance of the development of a Chikungunya vaccine. |
Databáze: | OpenAIRE |
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