Biological Activity of Novel N-Substituted Amides of endo-3- (3-Methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene-2- carboxylic Acid and N-Substituted Amides of 1-(5-Methylthio- 1,2,4-triazol-3-yl)cyclohexane-2-carboxylic Acids
| Autor: | Anna Pachuta-Stec, Urszula Kosikowska, Ewa Jagiełło-Wójtowicz, Anna Malm, Monika Pitucha, Anna Chodkowska |
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| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Analgesics Primary (chemistry) Bacteria Bicyclic molecule Cyclohexane Chemistry Carboxylic acid Carboxylic Acids Fungi Biological activity Microbial Sensitivity Tests Condensation reaction Amides Medicinal chemistry General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Anti-Infective Agents Ene reaction |
| Zdroj: | Zeitschrift für Naturforschung C. 67:123-128 |
| ISSN: | 1865-7125 0939-5075 |
| DOI: | 10.1515/znc-2012-3-403 |
| Popis: | N-Substituted amides of endo-3-(3-methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene- 2-carboxylic acid and 1-(5-methylthio-1,2,4-triazol-3-yl)cyclohexane-2-carboxylic acid were prepared by the condensation reaction of endo-S-methyl-N1-(bicyclo[2.2.1]hept-5-ene-2,3- dicarbonyl)isothiosemicarbazide and S-methyl-N1-(cyclohexane-2,3-dicarbonyl)isothiosemicarbazide with primary amines. The synthesized compounds were screened for their microbiological and pharmacological activities |
| Databáze: | OpenAIRE |
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