Intestinal perforation in very-low-birth-weight infants with necrotizing enterocolitis
| Autor: | Adriana Hernandez, Elena Dlugy, Tina Herscovici, Elena Fridman, Naama Hammel, Nehama Linder, Gil Klinger |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Neonatal intensive care unit Vlbw infants Risk Assessment Enterocolitis Necrotizing Risk Factors medicine Humans Infant Very Low Birth Weight Retrospective Studies Enterocolitis business.industry NEC - Necrotizing enterocolitis Case-control study Infant Newborn Retrospective cohort study General Medicine medicine.disease digestive system diseases Low birth weight Intestinal Perforation Case-Control Studies Pediatrics Perinatology and Child Health Necrotizing enterocolitis Surgery Female medicine.symptom business |
| Zdroj: | Journal of pediatric surgery. 48(3) |
| ISSN: | 1531-5037 |
| Popis: | To identify risk factors for intestinal perforation in very-low-birth-weight (VLBW) infants with necrotizing enterocolitis (NEC).Retrospective case-control study over a 10-year period, using univariate and multivariate logistic regression analyses to compare all VLBW infants treated for perforated NEC, with two age and weight-matched groups: infants with non-perforated NEC and infants without NEC.Twenty infants with perforated NEC were matched to 20 infants with non-perforated NEC and 38 infants without NEC. Infants with perforated NEC were younger (p0.01) and had higher rates of abdominal distention, metabolic acidosis, hyperglycemia and elevated liver enzymes (p0.05). On logistic regression analysis, abdominal distention was associated with an increased risk of intestinal perforation (OR 39.8, 95% CI 2.71-585) and late onset of NEC (one-day increments) was associated with a decreased risk (OR 0.93, 95% CI 0.87-1.0).Identification of abdominal distention at an early age in VLBW infants should lead to increased vigilance for signs of perforated NEC and may enable early intervention. |
| Databáze: | OpenAIRE |
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