Modulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery system
| Autor: | Paolo Costantino, Barbara Baudner, J. Coos Verhoef, Hans E. Junginger, Maurizio Morandi, Rino Rappuoli, Giuseppe Del Giudice, Marzia Monica Giuliani |
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| Rok vydání: | 2003 |
| Předmět: |
Chitin
Meningococcal Vaccines Enterotoxin Meningococcal vaccine Neisseria meningitidis Serogroup C Biology Meningitis Meningococcal Microbiology Mice Immune system Drug Delivery Systems Adjuvants Immunologic Conjugate vaccine Immunology and Allergy Animals Administration Intranasal Chitosan Drug Carriers Mice Inbred BALB C Immunogenicity Disease Models Animal Infectious Diseases Immunization biology.protein Nasal administration Female Antibody |
| Zdroj: | The Journal of infectious diseases. 189(5) |
| ISSN: | 0022-1899 |
| Popis: | Previous work had shown that the immunogenicity of conjugate vaccine against group C meningococci (CRM-MenC) is enhanced when it is delivered intranasally (inl) with mucosal adjuvants, such as mutants of the Escherichia coli enterotoxin (LT), and with delivery systems such as chitosan derivatives. We show, in mice, that the concomitant use of limiting doses of the fully nontoxic LTK63 mutant as a mucosal adjuvant and of the trimethyl derivative of chitosan as a delivery system allows the reduction of each of the components for the induction of antibody and bactericidal responses to CRM-MenC conjugate vaccine delivered inl at titers similar to or higher than those induced by parenteral immunization. These data could affect the design of efficacious mucosal vaccines and their safety. |
| Databáze: | OpenAIRE |
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