Roles of hematocrit and fibrinogen in red cell aggregation determined by ultrasonic scattering properties
| Autor: | Jeffery Justin, Andrew Kalisz, Bernard Sigel, Joan Sokil-Melgar, Ernest J. Feleppa, Hiroshi Kitamura, J Machi |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Erythrocyte Aggregation Male Diffusion (acoustics) Erythrocytes Materials science Acoustics and Ultrasonics Biophysics Analytical chemistry Hematocrit Optics Spectral slope medicine Humans Scattering Radiation Radiology Nuclear Medicine and imaging Ultrasonography Radiological and Ultrasound Technology medicine.diagnostic_test Scattering business.industry Fibrinogen Spectral density Cell aggregation Transducer Ultrasonic sensor Rheology business |
| Zdroj: | Ultrasound in Medicine & Biology. 21:827-832 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/0301-5629(95)00022-j |
| Popis: | Parameters of the power spectrum of backscattered echoes were applied to quantitatively evaluate red cell aggregation in vitro . Human red cell suspensions were circulated in a closed loop of tubing, and ultrasonic, radiofrequency, echo-signal data were obtained using a 10-MHz transducer. Data acquisition was performed at 30-s to 1-min intervals for 5 min after flow stoppage. Two parameters of the normalized power spectrum of the echo signals, spectral slope and Y -intercept, were computed, and estimates of two scattering properties, the scatterer size and acoustic concentration were calculated from these parameters using equations based on scattering theroy. Size and acoustic concentration were observed as they changed over time after the stoppage of flow. The key findings were that hematocrit affected the rate of cell aggregation while fibrinogen controlled aggregate size and acoustic concentration. |
| Databáze: | OpenAIRE |
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