Concurrent radiotherapy and chemotherapy with protracted continuous infusion of 5-fluorouracil in inoperable esophageal squamous cell carcinoma
| Autor: | Tadashi Sugita, Junichi Oda, Akira Saito, Hiroo Sueyama, Kunio Sakai, Emiko Tsuchida, Yasuo Matsumoto, Takeshi Ito, Mari Saito, Hideki Inakoshi |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Pilot Projects Carcinoma medicine Humans Combined Modality Therapy Radiology Nuclear Medicine and imaging Prospective Studies Esophagus Aged Chemotherapy Radiation Radiotherapy Esophageal disease business.industry Middle Aged medicine.disease Surgery Radiation therapy medicine.anatomical_structure Oncology Fluorouracil Carcinoma Squamous Cell Feasibility Studies Female Radiology business Chemoradiotherapy medicine.drug |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 31:921-927 |
| ISSN: | 0360-3016 |
| Popis: | The feasibility of a concurrent chemoradiotherapeutic protocol for patients with inoperable esophageal squamous cell carcinoma was tested.Concurrent chemoradiotherapy using protracted low-dose continuous infusions of five-fluorouracil (5-FU; 250-300 mg/m2/24 h) and standard external beam irradiation was given to 28 patients with inoperable esophageal squamous cell carcinoma between November 1991 and June 1993.For 25 patients receiving a total dose ofor = 60 Gy and concurrent 5-FU infusion for more than 5 weeks, the complete response rate was 52%. Local progression-free rate in this chemoradiotherapy group was significantly higher than the historical controls treated by radiotherapy alone (p0.05). A multivariate analysis revealed the treatment scheme (concomitant chemoradiotherapy vs. radiotherapy alone) to be a significant factor in local control (p0.01). Swallowing pain (39%), anorexia (39%), and nausea (32%) were the most frequent early reactions. Serious late radiation complications have not been observed.The concurrent chemoradiotherapy using protracted low-dose continuous infusion of 5-FU and standard radiotherapy is an effective and safe method to obtain a local control in inoperable esophageal squamous cell carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|