Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children

Autor: Peder Skov Wehner, Mikael Thastum, Nini Kyvsgaard, Torben Stamm Mikkelsen, Karsten Nysom, Troels Herlin, Anne Estmann Christensen
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Parents
Medical Doctors
genetic structures
Health Care Providers
Treatment outcome
Arthritis
Social Sciences
Pathology and Laboratory Medicine
Hematologic Cancers and Related Disorders
0302 clinical medicine
Antirheumatic Agents/administration & dosage
immune system diseases
Internal consistency
Medicine and Health Sciences
Medicine
Psychology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
Medical Personnel
Arthritis
Juvenile/drug therapy
Child
skin and connective tissue diseases
Methotrexate/administration & dosage
Routes of Administration
Multidisciplinary
Drugs
Nausea
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Lymphoblastic Leukemia
Leukemia
Professions
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Antirheumatic Agents
Child
Preschool
Lymphoblastic Leukemia
Female
medicine.symptom
medicine.drug
Research Article
musculoskeletal diseases
medicine.medical_specialty
Adolescent
Science
Immunology
Rheumatoid Arthritis
Autoimmune Diseases
03 medical and health sciences
Signs and Symptoms
Rheumatology
Diagnostic Medicine
Internal medicine
Physicians
Leukemias
Juvenile
Humans
Juvenile Idiopathic Arthritis
030203 arthritis & rheumatology
Pharmacology
Behavior
business.industry
Cancers and Neoplasms
Biology and Life Sciences
Infant
medicine.disease
Arthritis
Juvenile
Health Care
Methotrexate
People and Places
Lymphoblastic leukaemia
Clinical Immunology
Population Groupings
Clinical Medicine
business
Zdroj: PLoS ONE, Vol 14, Iss 7, p e0219539 (2019)
Kyvsgaard, N, Mikkelsen, T S, Thastum, M, Christensen, A E, Wehner, P S, Nysom, K & Herlin, T 2019, ' Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children ', PLOS ONE, vol. 14, no. 7, e0219539 . https://doi.org/10.1371/journal.pone.0219539
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0219539
Popis: OBJECTIVES: To analyse the internal consistency of an adaption of the methotrexate intolerance severity score (MISS); and to describe and compare the level of methotrexate intolerance evaluated by the MISS in Danish children with juvenile idiopathic arthritis (JIA) or acute lymphoblastic leukaemia (ALL), treated with low-dose methotrexate (MTX).METHODS: Cross-sectional study of children diagnosed with JIA or ALL, treated with low-dose MTX, aged 9 years or above, and cognitively intact. The patient's parents completed the MISS. MTX intolerance was defined as a total MISS score above 6.RESULTS: We enrolled 120 children with JIA and 23 children with ALL. The MISS had a good internal consistency in the JIA group. The median MISS score was higher in the JIA group than in the ALL group (JIA: 8; ALL: 1; pCONCLUSION: In the JIA group the level of MTX intolerance was higher and more attributed to anticipatory, associative and behavioural symptoms than in the ALL group. The MISS may help to uncover whether MTX intolerance is present and which aspects are affected in the individual patient, thus guiding intervention. The MISS may also be applicable within leukaemia care.
Databáze: OpenAIRE
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