A novel hyaluronan-based gel in laparoscopic adhesion prevention: preclinical evaluation in an animal model
| Autor: | Massimo Dona, Pier Andrea De Laco, Simonetta Piana, Luciano Bovicelli, Daniele Pressato, Marco Stefanetti, Alessandra Pavesio |
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| Rok vydání: | 1998 |
| Předmět: |
Laparoscopic surgery
medicine.medical_specialty Biopsy medicine.medical_treatment Adhesion (medicine) Tissue Adhesions Cohort Studies Lesion Random Allocation chemistry.chemical_compound Laparotomy Hyaluronic acid medicine Animals Hyaluronic Acid Laparoscopy medicine.diagnostic_test business.industry Uterus Obstetrics and Gynecology Uterine horns medicine.disease Surgery Reproductive Medicine chemistry Female Rabbits medicine.symptom business Gels |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(98)00496-8 |
| Popis: | Objective: To evaluate the effectiveness of a crosslinked hyaluronan solution (ACP gel) in the prevention of postsurgical adhesions in laparoscopic surgery. Design: A randomized blinded study using a rabbit model in laparoscopic surgery. Setting: A standardized surgical trauma in the rabbit uterine horn to induce adhesion formation. Animals: Sixty-four sexually matured female New Zealand white rabbits weighing 2.5 to 3.0 kg and aged 3–4 months. Intervention(s): After trauma, group 1 (n = 22) received no treatment, group 2 animals (n = 20) received oxidized-regenerated cellulose (Interceed [TC71), in group 3 (n = 22) 5 mL of ACP gel were applied on the lesion. Main Outcome Measure(s): Six weeks after laparoscopy, a laparotomy was performed and the adhesions were scored according to Blauer's scoring system. Result(s): 66% of the untreated animals and 85% of the animals treated with Interceed presented with severe adhesions, whereas only 35% of the ACP gel treatment group had significant adhesions. The mean (± SEM) increased adhesion score was 2.24 ± 0.26 in the untreated group, 2.45 ±0.22 in the Interceed group, and was 1.25 ± 0.28 in the ACP gel group. Conclusion(s): This study revealed that ACP gel holds promise as a novel resorbable biomaterial for the reduction of postoperative adhesions after laparoscopic surgery. |
| Databáze: | OpenAIRE |
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