Efficient synthesis of cRGD functionalized polymers as building blocks of targeted drug delivery systems
| Autor: | Hajeeth Thankappan, Damla Taykoz, Aykut Zelcak, Volga Bulmus |
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| Přispěvatelé: | Thankappan, Hajeeth, Zelçak, Aykut, Taykoz, Damla, Bulmuş, Volga, Izmir Institute of Technology. Biotechnology and Bioengineering, Izmir Institute of Technology. Chemical Engineering, Izmir Institute of Technology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Polymers and Plastics
General Physics and Astronomy 02 engineering and technology 010402 general chemistry Methacrylate 01 natural sciences Polymeric nanoparticles chemistry.chemical_compound Materials Chemistry Reversible addition−fragmentation chain-transfer polymerization chemistry.chemical_classification Acrylate Targeted drug delivery RAFT polymerization RGD Chemistry Organic Chemistry End-group functionalization Raft Polymer 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences Monomer Polymerization 0210 nano-technology |
| Popis: | Bulmus, Volga/0000-0001-9944-1444 WOS: 000434745200044 Synthetic peptides with cyclic arginine-glycine-aspartate motif (cRGD) play an important role in cell recognition and cell adhesion. cRGD-decorated soluble polymers and polymeric nanoparticles have been increasingly used for cell-specific delivery of antitumor drugs. While the significance of cRGD modification for tumor cell-specific targeting of polymeric carriers is well-accepted, straightforward procedures ensuring the fidelity of cRGD modification of polymeric systems are still lacking. Herein, we have reported an in-situ polymerization approach for synthesis of cRGD-end-functionalized well-defined polymers as potential building blocks of targeted drug delivery systems. A new cRGD peptide functionalized RAFT agent was synthesized as confirmed by MALDI-TOF and H-1 NMR spectroscopy. The ability of this RAFT agent to control polymerizations was then tested using two different monomers oligoethyleneglycol acrylate and t-butyl methacrylate. The RAFT-controlled character of polymerizations and the living characteristic of the synthesized polymers were investigated through a series of kinetic experiments. The cytotoxicity and targeting capability of cRGD-functionalized OEGA polymers were investigated using cell lines expressing alpha(v)beta(3) integrins at varying extents. |
| Databáze: | OpenAIRE |
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