Solid-Phase Synthesis of Peptidomimetic Inhibitors for the Hepatitis C Virus NS3 Protease
| Autor: | Marc-André Poupart, Ghiro Elise, Youla S. Tsantrizos, Nathalie Goudreau, Catherine Chabot, Dale R. Cameron, Sylvie Goulet, Martin Poirier |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Peptidomimetic
viruses medicine.medical_treatment Hepatitis C virus Viral Nonstructural Proteins medicine.disease_cause Structure-Activity Relationship Solid-phase synthesis Peptide Library medicine Combinatorial Chemistry Techniques Humans Enzyme Inhibitors Serine protease chemistry.chemical_classification NS3 Protease biology Molecular Mimicry Organic Chemistry virus diseases biochemical phenomena metabolism and nutrition digestive system diseases NS2-3 protease Enzyme chemistry Biochemistry biology.protein Oligopeptides |
| Zdroj: | The Journal of Organic Chemistry. 66:4743-4751 |
| ISSN: | 1520-6904 0022-3263 |
| DOI: | 10.1021/jo010164d |
| Popis: | The NS3 serine protease enzyme of the hepatitis C virus (HCV) is essential for viral replication. Short peptides mimicking the N-terminal substrate cleavage products of the NS3 protease are known to act as weak inhibitors of the enzyme and have been used as templates for the design of peptidomimetic inhibitors. Automated solid-phase synthesis of a small library of compounds based on such a peptidomimetic scaffold has led to the identification of potent and highly selective inhibitors of the NS3 protease enzyme. |
| Databáze: | OpenAIRE |
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