Microwave fluorination: a novel, rapid approach to fluorination with Selectfluor®
| Autor: | Gavin W. Bluck, Neil Brian Carter, Turnbull Michael Drysdale, Stephen C. Smith |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Organic Chemistry
Electrophilic fluorination Halogenation General Medicine Combinatorial chemistry Biochemistry Inorganic Chemistry chemistry.chemical_compound Key factors chemistry Microwave heating Reagent Microwave irradiation Environmental Chemistry Organic chemistry Physical and Theoretical Chemistry Acetonitrile Selectfluor Microwave |
| Zdroj: | Journal of Fluorine Chemistry. 125:1873-1877 |
| ISSN: | 0022-1139 |
| DOI: | 10.1016/j.jfluchem.2004.06.015 |
| Popis: | Fluorination of electron rich aromatic systems with electrophilic fluorination reagents such as Selectfluor ® and Accufluor ® is a well-established process. Herein we report results from investigations into the use of such procedures to perform rapid, small-scale fluorinations under microwave irradiation. We have investigated the transformation with a range of different substrates and discuss the effects of two key factors, namely reaction time and choice of fluorination reagent. The use of Selectfluor ® in acetonitrile at 150 °C with microwave heating for 10 min affords products in comparable yields to those obtained by prolonged heating in acetonitrile at its reflux temperature. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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