Expression of glutathione S-transferase activity and glutathione content in squamous cell carcinoma of bladder associated with schistosomiasis in a population in Egypt
| Autor: | Ahmed Mahmoud, Mohamed A. A. El-aziz, Amalia Lafuente, Galal E. M. D. Ghazaly, Madeha M. Zakahary, Pablo Carretero |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Urology Population Urinary Bladder Schistosomiasis Gene Expression Regulation Enzymologic chemistry.chemical_compound Schistosomiasis haematobia Medicine Transferase Humans education Aged Glutathione Transferase education.field_of_study Urinary bladder Bladder cancer biology business.industry Glutathione Middle Aged medicine.disease Molecular biology medicine.anatomical_structure Glutathione S-transferase Cell Transformation Neoplastic chemistry Epidermoid carcinoma Urinary Bladder Neoplasms Nephrology Drug Resistance Neoplasm biology.protein Carcinoma Squamous Cell Egypt Female business |
| Zdroj: | Scandinavian journal of urology and nephrology. 31(1) |
| ISSN: | 0036-5599 |
| Popis: | The present study was designed to describe the expression of the glutathione S-transferase/glutathione system in squamous cell carcinoma of the bladder in a population in Egypt. The glutathione-S transferase activity was significantly higher in bladder cancer specimens (n = 40) in comparison with schistosomiasis cystitis tissue (n = 42) (4-fold, p = 1 x 10(-12)) and with healthy control samples (n = 9) (10-fold, p = 1 x 10(-6)). The glutathione content was also significantly higher in bladder cancer than in cystitis tissue (2-fold, p = 8 x 10(-6)) and in control samples (6-fold, 8 x 10(-6)). When control mucosa and cystitis samples were compared, 2-fold increased values were obtained for glutathione-S transferase (p = 4 x 10(-3)) and glutathione (p = 1 x 10(-3)) in schistosomiasis bladder tissue. Results describe an over-expression of glutathione-S transferase and glutathione levels in squamous cell carcinoma of the bladder, and indicate a possible role in chemoresistance to pharmacological therapy. |
| Databáze: | OpenAIRE |
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