Polymorphisms in key bone modulator cytokines genes influence bisphosphonates therapy in postmenopausal women
| Autor: | J de Azevêdo Silva, Paulo Roberto Eleutério de Souza, A. P. O. Souza, Sergio Crovella, Camilla Albertina Dantas de Lima, Paula Sandrin-Garcia, André Barbosa, A. P. M. C. Valença, N. R. Javorski |
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| Přispěvatelé: | Lima, C. A. D., Javorski, N. R., Souza, A. P. O., Barbosa, A. D., Valença, A. P. M. C., Crovella, Sergio, Souza, P. R. E., De Azevedo Silva, J., Sandrin Garcia, P. |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Immunology Osteoporosis Parathyroid hormone Single-nucleotide polymorphism Polymorphism Single Nucleotide Proinflammatory cytokine Bone biochemical markers Bone mineral density Genetics of osteoporosis Osteoimmunology Osteoporosis therapy 03 medical and health sciences 0302 clinical medicine Bone Density Internal medicine Vitamin D and neurology medicine Humans Bone biochemical marker Pharmacology (medical) Osteoporosis Postmenopausal Aged Pharmacology Bone mineral Diphosphonates Genetics of osteoporosi business.industry Middle Aged Bisphosphonate medicine.disease Postmenopause 030104 developmental biology Endocrinology 030220 oncology & carcinogenesis Cytokines Female Bone Remodeling IL17A business |
| Zdroj: | Inflammopharmacology. 25:191-201 |
| ISSN: | 1568-5608 0925-4692 |
| DOI: | 10.1007/s10787-017-0322-7 |
| Popis: | Osteoporosis is a multifactorial and debilitating disease resulting from decreased bone mineral density (BMD) and loss of tissue microarchitecture. Ineffective therapies may lead to bone fractures and subsequent death. Single nucleotide polymorphisms (SNPs) in key immune regulator genes have been associated with therapeutic response to bisphosphonates, which are the first therapeutic line of choice for osteoporosis. However, cytokine pathways and their relation with therapeutic adhesion remain to be fully elucidated. Aimed at better understanding these processes, we investigated the response to bisphosphonate therapy in postmenopausal women and four SNPs in key proinflammatory cytokines genes: IL23R +2284 (C>A) (rs10889677), IL17A +672 (G>A) (rs7747909), IL12B +1188 (T>G) (rs3212227) and INF-γ -1616 (G>A) (rs2069705). A total of 69 patients treated with bisphosphonate were followed for a period of 1 up to 4 years, genotyped and compared according to their changes in bone mineral density (BMD) and level of biochemical markers during their treatment. The INF-γ -1616 G/G associated with increased BMD values in femoral neck (GG/AA, p = 0.016) and decreased BMD values in total hip (GG/GA, p = 0.019; GG/AA, p = 0.011). In relation to biochemical markers, INF-γ -1616 SNP associated with increased alkaline phosphatase (GG/AA; p |
| Databáze: | OpenAIRE |
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