Occupational Years of Service and Leukocyte Epigenetic Aging: Relationships in United States Firefighters
| Autor: | Jamaji C. Nwanaji-Enwerem, Andres Cardenas, Jaclyn M. Goodrich, Melissa A. Furlong, Alesia M. Jung, Philip A. Collender, Alberto J. Caban-Martinez, Casey Grant, Shawn C. Beitel, Sally Littau, Derek J. Urwin, Jamie J. Gabriel, Jeff Hughes, John Gulotta, Darin Wallentine, Jefferey L. Burgess |
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| Rok vydání: | 2023 |
| Předmět: |
Aging
epigenetic age DNA methylation EMS Public Health Environmental and Occupational Health EMT Nursing United States Environmental & Occupational Health Good Health and Well Being Genetic healthy worker effect Firefighters Leukocytes Genetics Public Health and Health Services Humans Longitudinal Studies Epigenesis |
| Zdroj: | Journal of occupational and environmental medicine, vol 65, iss 5 |
| Popis: | ObjectiveThe aim of the study is to examine associations between years of firefighting service and eight chronological age-adjusted measures of blood leukocyte epigenetic age acceleration: Horvath, Hannum, SkinBloodClock, Intrinsic, Extrinsic, PhenoAge, GrimAge, and DNAm telomere length.MethodsThe study used a repeated measures analysis of data from 379 incumbent firefighters from eight career departments and 100 recruit firefighters from two of the departments, across the United States.ResultsIncumbent firefighters had on average greater epigenetic age acceleration compared with recruit firefighters, potentially due to the cumulative effect of occupational exposures. However, among incumbent firefighters, additional years of service were associated with epigenetic age deceleration, particularly for GrimAge, a strong predictor of mortality.ConclusionsLong-term studies with more specific occupational exposure classification are needed to better understand the relationship between years of service and aging biomarkers. |
| Databáze: | OpenAIRE |
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