The role of a2ß1 integrin in anchorage dependent apoptosis of breast carcinoma and hepatoma cells

Autor:	Berman, A. E., Kozlova, N. I., Morozevich, G. E., Preobrazhenskaya, M. E., Shtil, A. A., Ushakova, N. A.
Jazyk:	angličtina
Rok vydání:	2007
Předmět:	anoikis extracellular matrix apoptosis integrins signaling
DOI:	10.17877/de290r-8188
Popis:	The role of collagen specific a2ß1 integrin in anchorage dependent apoptosis (anoikis) was investigated. Stimulation of a2ß1 signaling with immobilized anti-a2 antibody markedly sensitized human MCF-7 breast carcinoma and HepG2 hepatoma cells to anoikis. Accordingly, down-regulation of a2ß1 by a2-specific siRNA decreased the percentage of cells undergoing anoikis. These results for the first time provide direct evidence that a2ß1 receptor can transduce the signal to promote death in matrix deprived cells. EXCLI Journal ; Vol. 6, 2007
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47345840f18900d774752f198538c806 Zobrazit plný text záznamu