Peripheral hemodynamic effects of ibopamine in patients with congestive heart failure. A placebo-controlled, double-blind study
| Autor: | G. F. Musacci, Tiziano Toselli, Silvio Aggio, P. Ghirardi, Carlo Longhini, Enrico Baracca, L. Ansani |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Vasodilator Agents Hemodynamics Vasodilation Placebo Double-Blind Method Heart Rate Internal medicine Ibopamine Humans Plethysmograph Medicine Pharmacology (medical) Aged Aged 80 and over Heart Failure Pharmacology business.industry General Medicine Middle Aged medicine.disease Peripheral Plethysmography Deoxyepinephrine Regional Blood Flow Heart failure Anesthesia Cardiology Female Sulpiride Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiovascular Drugs and Therapy. 3:199-202 |
| ISSN: | 1573-7241 0920-3206 |
| DOI: | 10.1007/bf01883865 |
| Popis: | Under double-blind conditions, 150 mg of ibopamine (di-isobutyric ester of N-methyldopamine) or placebo were given orally to 11 patients with congestive heart failure; after 3 hours, 50 mg of sulpiride were administered intramuscularly. Peripheral hemodynamics were evaluated at the level of the forearm using strain-gauge plethysmography. Ibopamine increased arterial blood flow and venous capacity and decreased arterial peripheral resistance; these effects were counteracted by sulpiride. No significant changes were observed after placebo and sulpiride. These findings confirm the vasodilating effects of ibopamine on peripheral hemodynamics and its utility in patients for the treatment of congestive heart failure. |
| Databáze: | OpenAIRE |
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