Bacteria Fighting Back: How Pathogens Target and Subvert the Host Innate Immune System
| Autor: | Neal M. Alto, L. Evan Reddick |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Innate immune system
Bacteria Antimicrobial peptides Models Immunological Pattern recognition receptor Cell Biology Biology Immunity Innate Article Microbiology Toll-Like Receptor 4 Classical complement pathway Immune system Immunity Receptors Pattern Recognition Host-Pathogen Interactions Antigenic variation Signal transduction Molecular Biology Immune Evasion Signal Transduction |
| Zdroj: | Molecular Cell. 54:321-328 |
| ISSN: | 1097-2765 |
| DOI: | 10.1016/j.molcel.2014.03.010 |
| Popis: | The innate immune system has evolved under selective pressure since the radiation of multicellular life approximately six hundred million years ago. Because of this long history, innate immune mechanisms found in modern eukaryotic organisms today are highly complex, yet are built from common molecular strategies. It is now clear that evolution has selected a conserved set of anti-microbial peptides as well as Pattern Recognition Receptors (PRRs) that initiate cellular-based signals as a first line of defense against invading pathogens. Conversely, microbial pathogens employ their own strategies to evade, inhibit, or otherwise manipulate the innate immune response. Here, we discuss recent discoveries that have changed our view of immune modulatory mechanisms employed by bacterial pathogens, focusing specifically on the initial sites of microbial recognition and extending to host cellular signal transduction, pro-inflammatory cytokine production, and alteration of protein trafficking and secretion. |
| Databáze: | OpenAIRE |
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