Cervical human papillomavirus infection among young women engaged in sex work in Phnom Penh, Cambodia: prevalence, genotypes, risk factors and association with HIV infection
| Autor: | Kimberly Page, Jennifer L. Evans, John M. Kaldor, Ellen Stein, Joel M. Palefsky, Lisa Maher, Marie-Claude Couture, Neth Sansothy, Keo Sichan |
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| Jazyk: | angličtina |
| Předmět: |
Adult
medicine.medical_specialty Multivariate analysis Adolescent Genotype HIV Infections Cervix Uteri Polymerase Chain Reaction lcsh:Infectious and parasitic diseases Young Adult 03 medical and health sciences 0302 clinical medicine Medical microbiology 5. Gender equality Risk Factors Prevalence medicine Humans lcsh:RC109-216 030212 general & internal medicine Papillomaviridae Genotyping Sex work Gynecology Cervical cancer Sex Workers business.industry Papillomavirus Infections HPV infection Cancer virus diseases medicine.disease 3. Good health Cross-Sectional Studies Infectious Diseases 030220 oncology & carcinogenesis DNA Viral Female Cambodia Oligonucleotide Probes business Research Article Demography |
| Zdroj: | Couture, Marie-Claude; Page, Kimberly; Stein, Ellen S; Sansothy, Neth; Sichan, Keo; Kaldor, John; et al.(2012). Cervical human papillomavirus infection among young women engaged in sex work in Phnom Penh, Cambodia: prevalence, genotypes, risk factors and association with HIV infection. BMC Infectious Diseases, 12(1), 166. doi: http://dx.doi.org/10.1186/1471-2334-12-166. Retrieved from: http://www.escholarship.org/uc/item/9d64d6z1 BMC Infectious Diseases, Vol 12, Iss 1, p 166 (2012) BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/1471-2334-12-166 |
| Popis: | Background Although cervical cancer is the leading cancer in Cambodia, most women receive no routine screening for cervical cancer and few treatment options exist. Moreover, nothing is known regarding the prevalence of cervical HPV or the genotypes present among women in the country. Young sexually active women, especially those with multiple sex partners are at highest risk of HPV infection. We examine the prevalence and genotypes of cervical HPV, as well as the associated risk factors among young women engaged in sex work in Phnom Penh, Cambodia. Methods We conducted a cross-sectional study among 220 young women (15–29 years) engaged in sex work in different venues including brothels or entertainment establishments, and on a freelance basis in streets, parks and private apartments. Cervical specimens were collected using standard cytobrush technique. HPV DNA was tested for by polymerase chain reaction (PCR) and genotyping using type-specific probes for 29 individual HPV types, as well as for a mixture of 10 less common HPV types. All participants were also screened for HIV status using blood samples. Multivariate logistic regression analyses were conducted to assess risk factors for any or multiple HPV infection. Results The prevalence of cervical HPV 41.1%. HPV 51 and 70 were the most common (5.0%), followed by 16 (4.6%), 71 (4.1%) and 81 (3.7%). Thirty-six women (16.4%) were infected with multiple genotypes and 23.3% were infected with at least one oncogenic HPV type. In multivariate analyses, having HIV infection and a higher number of sexual partners were associated with cervical HPV infection. Risk factors for infection with multiple genotypes included working as freelance female sex workers (FSW) or in brothels, recent binge use of drugs, high number of sexual partners, and HIV infection. Conclusions This is the first Cambodian study on cervical HPV prevalence and genotypes. We found that HPV infection was common among young FSW, especially among women infected with HIV. These results underscore the urgent need for accessible cervical cancer screening and treatment, as well as for a prophylactic vaccine that covers the HPV subtypes present in Cambodia. |
| Databáze: | OpenAIRE |
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