Insignificant Immune Phagocytosis Inhibition and Cytotoxicity by the Murine Monoclonal HLA-DP Antibody B7/21 Tested on Human Monocytes and Macrophages
| Autor: | J. Neppert |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
HLA-DP Antigens
medicine.drug_class Immunology Cell HLA-DP Biology Monoclonal antibody Monocytes Flow cytometry Phagocytosis Antigen medicine Humans Cytotoxicity B-Lymphocytes medicine.diagnostic_test Macrophages Histocompatibility Antigens Class II Antibodies Monoclonal General Medicine Cytotoxicity Tests Immunologic Flow Cytometry Molecular biology medicine.anatomical_structure Monoclonal biology.protein Antibody |
| Zdroj: | Scandinavian Journal of Immunology. 24:321-326 |
| ISSN: | 0300-9475 |
| Popis: | On the basis of fluorescence flow cytometry data with the monoclonal antibody (MoAb) B7/21, and of the differing cell sizes, the HLA-DP antigen density on monocytes is estimated to be 25% of that on B lymphocytes. The remote positions of the antigens are assumed to be responsible for the markedly reduced inhibitory capacity of the MoAb B7/21 in immune phagocytosis by monocytes and for the absence of complement-dependent cytotoxicity of this MoAb to monocytes. The findings from experiments on peritoneal macrophages are comparable. Therefore HLA-DP may not be important for the functioning of the monocytes and macrophages. |
| Databáze: | OpenAIRE |
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