Evaluation of Glutathione S-transferase T1 (GSTT1) deletion polymorphism on type 2 diabetes mellitus risk in a sample of Yazdian females in Yazd, Iran
| Autor: | Afrand, Mohammadhosain, Saeedhossein Khalilzadeh, Froozan-Nia, Seyed Khalil, Sheikhha, Mohammad Hasan |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Electronic Physician Electronic Physician, Vol 6, Iss 3, Pp 856-862 (2014) |
| DOI: | 10.6084/m9.figshare.1067043.v1 |
| Popis: | Background: There has been much interest in the role of free radicals and oxidative stress in the pathogenesis ofdiabetes mellitus (DM). The aim of this study was to assess the possible association between genetic polymorphismsof the glutathione S-transferase-mu (GSTT1) and the risk of the development of DM in a sample of Yazdian femalesin Yazd, Iran.Methods: This was a case-control study in which GSTT1 polymorphism was genotyped in 51 randomly selectedDM patients and 50 randomly selected healthy controls among Yazdian females whose ages ranged from 40 to 70.Results: The frequencies of GSTT1 null genotype and GSTT1 present were 8 and 92%, respectively, in the controlsamples. In patients with type 2 diabetes (T2DM), the frequencies of GSTT1 null genotype and GSTT1 present were14 and 86%, respectively. There were higher levels of triglycerides (TG), fasting blood sugar (FBS), totalcholesterol (TC), low density lipoprotein (LDL), body mass index (BMI), and high density lipoprotein (HDL) inpatients with GSTT1 null genotype than in patients with the GSTT1 present genotype.Conclusions: Our results indicated that the GSTT1 deletion polymorphism is a risk factor for T2DM. We did notdetermine any significant association between the GSTT1 null genotype and T2DM. |
| Databáze: | OpenAIRE |
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