Physiology and treatment of myxedema

Autor: John G. Wiswell, Samuel P. Asper
Rok vydání: 1956
Předmět:
Zdroj: The American Journal of Medicine. 20:732-744
ISSN: 0002-9343
DOI: 10.1016/0002-9343(56)90155-3
Popis: Deficiency of the thyroid hormone in man results in retardation of many bodily functions and metabolic processes. Despite extensive studies, both in man and animals, which have delineated and defined some of the metabolic aberrations occurring in myxedema, the exact nature and mechanism of action of the thyroid hormone remain unidentified. The diagnosis of myxedema is established by recognition of the symptoms and physical manifestations which result from lack of thyroid hormone as well as by several ancillary laboratory procedures. Myxedema is most often due to ablation or spontaneous idiopathic atrophy of the thyroid, although other specific mechanisms may lead to failure of production of thyroid hormone. Treatment of thyroid deficiency consists of hormone replacement therapy with desiccated thyroid, thyroxine or triiodothyronine. Administration of one of these preparations daily in adequate dosage restores the patient to an apparently normal metabolic status. These medications are effective when administered orally. The results of therapy are gratifying.
Databáze: OpenAIRE