DIGGER: exploring the functional role of alternative splicing in protein interactions
| Autor: | Zakaria Louadi, Tim Kacprowski, Markus List, Kevin Yuan, Alexander Gress, Olga V. Kalinina, Jan Baumbach, Olga Tsoy |
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| Přispěvatelé: | IPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular Protein Conformation alpha-Helical Proteome AcademicSubjects/SCI00010 Systems biology Computational biology Biology Interactome Protein–protein interaction 03 medical and health sciences Exon 0302 clinical medicine Protein structure Protein Interaction Mapping Genetics Database Issue Humans Protein Isoforms Protein Interaction Domains and Motifs RNA Messenger Databases Protein 030304 developmental biology 0303 health sciences Internet Binding Sites Repertoire Alternative splicing Computational Biology Exons ddc Alternative Splicing Protein Biosynthesis Thermodynamics Protein Conformation beta-Strand 030217 neurology & neurosurgery Software Protein Binding |
| Zdroj: | Nucleic acids research England Louadi, Z, Yuan, K, Gress, A, Tsoy, O, Kalinina, O V, Baumbach, J, Kacprowski, T & List, M 2021, ' DIGGER : exploring the functional role of alternative splicing in protein interactions ', Nucleic acids research, vol. 49, no. D1, pp. D309-D318 . https://doi.org/10.1093/nar/gkaa768 Nucleic Acids Research |
| Popis: | Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friendly database DIGGER is available at https://exbio.wzw.tum.de/digger and allows users to seamlessly switch between isoform and exon-centric views of the interactome and to extract sub-networks of relevant isoforms, making it an essential resource for studying mechanistic consequences of alternative splicing. |
| Databáze: | OpenAIRE |
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