Alginate-zinc (II) phthalocyanine conjugates: Synthesis, characterization and tumor-associated macrophages-targeted photodynamic therapy
| Autor: | Qing-Yan Hu, Li Sicong, Tang Fengxiang, Wei Xie, Jian-Dong Huang, Bi-Yuan Zheng, Mei-Rong Ke |
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| Rok vydání: | 2020 |
| Předmět: |
Indoles
Polymers and Plastics Alginates medicine.medical_treatment Sodium chemistry.chemical_element Photodynamic therapy Antineoplastic Agents 02 engineering and technology Tumor-associated macrophage Zinc Nanoconjugates Conjugated system Isoindoles 010402 general chemistry 01 natural sciences chemistry.chemical_compound Mice Neoplasms Tumor-Associated Macrophages Materials Chemistry medicine Animals Humans Drug Carriers Photosensitizing Agents Organic Chemistry Hep G2 Cells 021001 nanoscience & nanotechnology Fluorescence Xenograft Model Antitumor Assays 0104 chemical sciences chemistry Photochemotherapy Cancer research Phthalocyanine 0210 nano-technology Conjugate |
| Zdroj: | Carbohydrate polymers. 240 |
| ISSN: | 1879-1344 |
| Popis: | Tumor-associated macrophages (TAMs)-targeted photodynamic therapy (PDT) has dual-selectivity and hence is promising in cancer treatment. Since the scavenger receptor-A (SR-A) on TAMs can recognize polyanions, two molecular-weight sodium alginates (SA1, 41.2 kDa; SA2, 1231.5 kDa) were herein respectively conjugated with 1-[4-(2-aminoethyl) phenoxy] zinc (II) phthalocyanine (1) and two novel conjugates were obtained, characterized and evaluated for their TAMs-targeted PDT efficacy. The SA introduction makes 1 water-soluble, less aggregated and capable of emitting considerable fluorescence in water. Compared with 1, both conjugates, especially 1-SA1, can give higher selectivity and photocytotoxicity to SR-A-positive macrophages J774A.1 than SR-A-negative HepG2 cells. The in vivo biodistribution evaluation shows both conjugates can selectively accumulate at the tumor site and 1-SA1 owns higher tumor accumulation. 1-SA1 can achieve an 87 % tumor inhibition rate without observable systemic toxicity. These results reveal the great potential of SA as a carrier for conjugating anti-tumor drugs and 1-SA1 for TAMs-targeted PDT. |
| Databáze: | OpenAIRE |
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