Immunohistochemical expression of nestin in rhabdomyosarcoma: implications for clinicopathology and patient outcome
| Autor: | Snežana Pejić, Jelena Sopta, D. Dundjerovic, Radoslav Davidovic, Relja Kovacevic, D. Ristic, Sofija Glumac |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Prognostic factor Adolescent Survival Gastroenterology Nestin 03 medical and health sciences 0302 clinical medicine Older patients Internal medicine Rhabdomyosarcoma Biomarkers Tumor Genetics medicine Overall survival Humans Child Molecular Biology Aged Neoplasm Staging 030304 developmental biology 0303 health sciences business.industry Infant Cancer General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry 3. Good health Gene Expression Regulation Neoplastic Clinicopathological significance Child Preschool 030220 oncology & carcinogenesis Immunology Clinicopathological features Female business |
| Zdroj: | Genetics and Molecular Research |
| Popis: | Rhabdomyosarcoma (RMS) is a highly malignant cancer. Over the last two decades, prognosis for RMS patients has significantly improved, with the exception of those in the high-risk group. In order to identify new prognostic factors, we investigated the expression of nestin in RMS cells and its correlation with clinicopathological features and patient outcome. The analysis of overall survival for all patients (N = 30) revealed 1-, 2-, 3-, 4-, and 5-year survival rates of 93.3, 83.3, 66.7, 63.3, and 63.3%, respectively. Nestin overexpression significantly correlated with survival (P = 0.044). Survival of patients with = 50% nestin-positive cells was 90, 70, and 40% after 1, 2, and 3 years, respectively, and remained unchanged until the end of the investigation period. The study group composed of patients exhibiting nestin expression in GT 50% of cells showed 1-, 2-, 3-, and 4-year survival rates of 95, 90, 80, and 75%, respectively, remaining stable at 75% for the fifth year of observation. A nestin-positive expression rate lower than 50% was observed more frequently in older patients (43.60 +/- 27.58 years; P = 0.028). In addition, higher rates of nestin expression were observed in most embryonal RMS specimens and low-grade tumors, in early stages of the disease, and among younger patients. Our results lead us to propose nestin as possible positive prognostic factor in RMS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|