Rutoside as mucosal protective in acetic acid-induced rat colitis
| Autor: | Antonio Zarzuelo, E. Crespo, T. Cruz, F. Sánchez de Medina, Julio Gálvez, M. A. Ocete, M. D. Lorente |
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| Rok vydání: | 1997 |
| Předmět: |
Antioxidant
Enterocyte Colon medicine.medical_treatment Rutin Pharmaceutical Science Administration Oral Inflammation Pharmacology Analytical Chemistry chemistry.chemical_compound Oral administration Drug Discovery Medicine Animals Colitis Intestinal Mucosa Rats Wistar Acetic Acid Peroxidase biology business.industry Organic Chemistry Glutathione medicine.disease Rats medicine.anatomical_structure Complementary and alternative medicine Biochemistry chemistry Intestinal Absorption Myeloperoxidase biology.protein Molecular Medicine Alkaline phosphatase medicine.symptom business |
| Zdroj: | Planta medica. 63(5) |
| ISSN: | 0032-0943 |
| Popis: | The effect of the flavonoid rutoside on acetic acid-induced rat colitis was studied. Rats were pretreated orally with different doses of the flavonoid (10, 25, and 100 mg/kg) 48, 24, and 1 hour prior to colitis induction and examined for colonic damage 24 hours later. Colonic inflammation was characterized by gross and microscopical injury, bowel wall thickening, abolition of fluid absorption, glutathione depletion, enhanced leukotriene B4 synthesis, and increased levels of myeloperoxidase and alkaline phosphatase activities. Rutoside treatment (25 and 100 mg/kg) reduced histologic injury and prevented the increase in alkaline phosphatase activity, but it had no effect on myeloperoxidase levels or leukotriene B4 synthesis. In addition, glutathione depletion was effectively counteracted at the dose of 25 mg/kg, whereas fluid absorption was achieved at the highest dose assayed. It is concluded that rutoside has an acute anti-inflammatory activity in this model which may be related to a putative direct protective effect on intestinal cells, mainly enterocytes, in which the antioxidative properties of the flavonoid may play a role. |
| Databáze: | OpenAIRE |
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