Cancer cells display increased migration and deformability in pace with metastatic progression
| Autor: | Zhenhui Liu, Se Jong Lee, Seungman Park, Kristine Glunde, Yun Chen, Ishan Barman, Konstantinos Konstantopoulos |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Epithelial-Mesenchymal Transition Lung Neoplasms Motility Apoptosis Breast Neoplasms Biology Biochemistry Article Parental cell Metastasis 03 medical and health sciences 0302 clinical medicine Circulating tumor cell Cell Movement Tumor Cells Cultured Genetics medicine Humans Neoplasm Metastasis Molecular Biology Cell Proliferation Amoeboid movement medicine.disease Isogenic human disease models Extravasation 030104 developmental biology Cancer cell Disease Progression Cancer research Female 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | FASEB J |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fj.202000101rr |
| Popis: | In this study, we explored the relation between metastatic states vs the capacity of confined migration, amoeboid transition, and cellular stiffness. We compared across an isogenic panel of human breast cancer cells derived from MDA-MB-231 cells. It was observed that cells after lung metastasis have the fastest migration and lowest stiffness, with a significantly higher capacity to transition into an amoeboid mode. Our findings illustrate that metastasis is a selective process favoring motile and softer cells. Moreover, the observation that circulating tumor cells resemble the parental cell line, but not lung-metastatic cells, suggests that cells with higher deformability and motility are likely selected during extravasation and colonization. |
| Databáze: | OpenAIRE |
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