The Clock Gene Rev-Erbα Regulates Methamphetamine Actions on Circadian Timekeeping in the Mouse Brain
| Autor: | Jorge E. Mendoza, Maria Mateo, Nora L. Salaberry |
|---|---|
| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty [SDV]Life Sciences [q-bio] Period (gene) Hypothalamus Neuroscience (miscellaneous) CLOCK Proteins Biology Methamphetamine 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Circadian rhythm ComputingMilieux_MISCELLANEOUS Mice Knockout Suprachiasmatic nucleus Meth Circadian Rhythm 3. Good health PER2 CLOCK Disease Models Animal 030104 developmental biology Endocrinology Neurology chemistry Light effects on circadian rhythm Nuclear Receptor Subfamily 1 Group D Member 1 Suprachiasmatic Nucleus Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Molecular Neurobiology Molecular Neurobiology, Humana Press, 2017, 54 (7), pp.5327-5334. ⟨10.1007/s12035-016-0076-z⟩ |
| ISSN: | 1559-1182 0893-7648 |
| Popis: | Circadian rhythms are strongly affected by drugs. In rodents, chronic methamphetamine (METH) intake changes circadian activity rhythms, mainly by altering light synchronization that generates the expression of a free-running rhythm with a period longer than 24 h and a second behavioral component that is independent of the main suprachiasmatic (SCN) clock. Although a number of clock genes do not appear to be involved in the effects of METH on circadian behavior, the molecular clockwork controlling these changes is still unclear. Therefore, we investigated the role of the clock gene Rev-Erbα in METH-induced behavioral and molecular responses using knockout mice and their wild-type littermates. Chronic intake of METH alters period circadian behavior of wild-type mice. However, in mice lacking the clock gene Rev-Erbα METH had no effect on their behavioral rhythms. Furthermore, PER2 bioluminescence rhythms in two extra-SCN brain oscillators, the dorsomedial hypothalamus and the habenula, were altered by METH in wild type but not in KO mice. Together, the present results implicate Rev-Erbα in the modulation of the circadian responses to METH and may provide a better comprehension into the mechanisms underlying circadian alterations provoked by drug addiction. |
| Databáze: | OpenAIRE |
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