Multimodal integrated sensor platform for rapid biomarker detection
| Autor: | Chunxiao Hu, V. F. Annese, Christos Giagkoulovits, David R. S. Cumming, Michael P. Barrett, Claudio Accarino, Boon Chong Cheah, Sandy Cochran, Srinivas Velugotla, Mohammed A. Al-Rawhani, Srinjoy Mitra, James Grant, James Beeley |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Computer science 0206 medical engineering Biomedical Engineering Biosensing Techniques 02 engineering and technology Integrated circuit Chemistry Techniques Analytical law.invention law Hardware_INTEGRATEDCIRCUITS Humans Nanotechnology Microelectronics Surface plasmon resonance Chemiluminescence business.industry Transistor Equipment Design Modular design Chip 020601 biomedical engineering Uric Acid Photodiode Cholesterol Semiconductors Single-photon avalanche diode business Biomarkers Computer hardware |
| ISSN: | 0018-9294 |
| Popis: | Precision metabolomics and quantification for cost-effective rapid diagnosis of disease are the key goals in personalized medicine and point-of-care testing. At present, patients are subjected to multiple test procedures requiring large laboratory equipment. Microelectronics has already made modern computing and communications possible by integration of complex functions within a single chip. As More than Moore technology increases in importance, integrated circuits for densely patterned sensor chips have grown in significance. Here, we present a versatile single complementary metal-oxide-semiconductor chip forming a platform to address personalized needs through on-chip multimodal optical and electrochemical detection that will reduce the number of tests that patients must take. The chip integrates interleaved sensing subsystems for quadruple-mode colorimetric, chemiluminescent, surface plasmon resonance, and hydrogen ion measurements. These subsystems include a photodiode array and a single photon avalanche diode array with some elements functionalized to introduce a surface plasmon resonance mode. The chip also includes an array of ion sensitive field-effect transistors. The sensor arrays are distributed uniformly over an active area on the chip surface in a scalable and modular design. Bio-functionalization of the physical sensors yields a highly selective simultaneous multiple-assay platform in a disposable format. We demonstrate its versatile capabilities through quantified bio-assays performed on-chip for glucose, cholesterol, urea, and urate, each within their naturally occurring physiological range. |
| Databáze: | OpenAIRE |
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