Left Hemispheric Deficit in the Sustained Neuromagnetic Response to Periodic Click Trains in Children with ASD
| Autor: | Kirill S Komarov, Tatiana M Ovsiannikova, Tatiana S. Obukhova, Tatiana A. Stroganova, Andrey O. Prokofyev, Dzerasa E. Goiaeva, Elena V. Orekhova |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
genetic structures business.industry media_common.quotation_subject Audiology Monaural medicine.disease behavioral disciplines and activities Vocal pitch Lateralization of brain function medicine.anatomical_structure Gyrus Perception mental disorders medicine Autism Right hemisphere Prosody business psychological phenomena and processes media_common |
| DOI: | 10.21203/rs.3.rs-48864/v1 |
| Popis: | Background: Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorders (ASD), but the neural basis of these abnormalities is unknown. In magnetoencephalogram (MEG), spectrally complex periodic sounds trigger two continuous neural responses – the Auditory Steady State Response (ASSR) and the Sustained Field (SF). It has been shown that the SF in neuro-typical individuals is associated with low-level analysis of pitch in the ‘pitch processing center’ of the Heschl’s gyrus. Therefore, this auditory response may reflect vocal pitch processing abnormalities in ASD. The SF, however, has never been studied in people with these disorders. Methods: We used MEG and individual brain models to investigate the ASSR and SF evoked by monaural 40 Hz click trains in 7-13-year-old boys with ASD (N=35) and neuro-typical (NT) boys (N=35). Results: In agreement with the previous research in adults, the cortical sources of the SF in children were located in the left and right Heschl’s gyri, anterolateral to those of the ASSR. In both groups, the SF and ASSR dominated in the right hemisphere and were higher contralaterally to the stimulated ear. The ASSR increased with age in both NT and ASD children and did not differ between the groups. The SF did not change between 7 and 13 years. It was moderately decreased in both hemispheres and was markedly delayed and displaced in the left hemisphere in boys with ASD. The SF delay in participants with ASD was present irrespective of their intelligence level and severity of autism symptoms. Limitations: We have not tested language abilities of our participants. Therefore, the link between SF and processing of vocal pitch in children with ASD remains speculative. Conclusion: The selective left-hemispheric SF abnormalities found in children with ASD are consistent with a deficit at a low level of pitch processing, which in turn may contribute to their difficulties in perception and production of linguistic prosody. |
| Databáze: | OpenAIRE |
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