Lipofilling in Breast Oncological Surgery: A Safe Opportunity or Risk for Cancer Recurrence?
| Autor: | Tiziana Triulzi, Elisabetta Scoccia, Lorena Signati, Carlo Morasso, Ilona Rybinska, Marta Truffi, Fabio Corsi, Alessandra Ricciardi, Francesca Piccotti |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Mammaplasty medicine.medical_treatment Breast surgery Adipose tissue Breast Neoplasms Review Catalysis lcsh:Chemistry Inorganic Chemistry oncological safety breast cancer Breast cancer Internal medicine medicine breast reconstruction Humans pre-clinical studies Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Mastectomy Spectroscopy business.industry Organic Chemistry Cancer Soft tissue General Medicine lipofilling medicine.disease Computer Science Applications breast cancer recurrence lcsh:Biology (General) lcsh:QD1-999 Adipose Tissue adipose-derived stromal cells Female Neoplasm Recurrence Local Breast reconstruction business |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 3737, p 3737 (2021) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22073737 |
| Popis: | Lipofilling (LF) is a largely employed technique in reconstructive and esthetic breast surgery. Over the years, it has demonstrated to be extremely useful for treatment of soft tissue defects after demolitive or conservative breast cancer surgery and different procedures have been developed to improve the survival of transplanted fat graft. The regenerative potential of LF is attributed to the multipotent stem cells found in large quantity in adipose tissue. However, a growing body of pre-clinical evidence shows that adipocytes and adipose-derived stromal cells may have pro-tumorigenic potential. Despite no clear indication from clinical studies has demonstrated an increased risk of cancer recurrence upon LF, these observations challenge the oncologic safety of the procedure. This review aims to provide an updated overview of both the clinical and the pre-clinical indications to the suitability and safety of LF in breast oncological surgery. Cellular and molecular players in the crosstalk between adipose tissue and cancer are described, and heterogeneous contradictory results are discussed, highlighting that important issues still remain to be solved to get a clear understanding of LF safety in breast cancer patients. |
| Databáze: | OpenAIRE |
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