Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes
| Autor: | Carolyn S. McBride, Thomas L. Carroll, Zhongyan Gong, Manu Prakash, Felix J. H. Hol, Trevor R. Sorrells, Veronica Jove, Zhilei Zhao, Leslie B. Vosshall |
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| Přispěvatelé: | Rockefeller University [New York], Interactions Virus-Insectes - Insect-Virus Interactions (IVI), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Stanford University, Princeton University, Kavli Neural Systems Institute, Howard Hughes Medical Institute [New York] (HHMI), Howard Hughes Medical Institute (HHMI)-New York University School of Medicine, NYU System (NYU)-NYU System (NYU)-Rockefeller University [New York]-Columbia University Irving Medical Center (CUIMC), This work was supported in part by NCATS NIH CTSA grant UL1 TR000043, NIH T32-MH095246 (to V.J.), an HHMI Gilliam fellowship (to V.J.), NSF DGE-1325261 (to V.J.), the CASI/Burroughs Wellcome Fund (to F.J.J.H.), Marie Skłodowska-Curie grant agreement 841893 – PiQiMosqBite (to F.J.J.H.), a Jane Coffin Childs postdoctoral fellowship (to T.R.S.), a Kavli Neural Systems Institute postdoctoral fellowship (to T.R.S.), NIDCD R00-DC012069 (to C.S.M.), NIH DP2-AI124336 (to M.P.), and a USAID Grand Challenges: Zika and Future Threats award (to M.P.). M.P. is an HHMI-Gates Faculty Scholar of the Howard Hughes Medical Institute. C.S.M. is a New York Stem Cell Foundation – Robertson Investigator. L.B.V. is an investigator of the Howard Hughes Medical Institute., European Project: 841893,H2020-MSCA-IF-2018,PiQiMosqBite(2019) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Taste nectar-feeding behavior MESH: Neurons gustatory receptors GCaMP calcium imaging ionotropic receptors MESH: Discrimination Psychological 0302 clinical medicine Aedes aegypti Discrimination Psychological Aedes MESH: Animals Neurons MESH: Plant Nectar General Neuroscience food and beverages Taste Perception MESH: Aedes 3. Good health Stylet medicine.anatomical_structure Blood MESH: Feeding Behavior stylet Plant Nectar education Zoology Sensory system mosquito Biology Article 03 medical and health sciences parasitic diseases medicine MESH: Blood Nectar Animals [SCCO.NEUR]Cognitive science/Neuroscience fungi Feeding Behavior Blood meal biology.organism_classification Sexual dimorphism 030104 developmental biology MESH: Taste Perception blood-feeding behavior chemogenetics MESH: Taste Neuron 030217 neurology & neurosurgery |
| Zdroj: | Neuron Neuron, 2020, 108 (6), pp.1163-1180.e12. ⟨10.1016/j.neuron.2020.09.019⟩ |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2020.09.019⟩ |
| Popis: | Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and nectar because each meal promotes mutually exclusive feeding programs with distinct sensory appendages, meal sizes, digestive tract targets, and metabolic fates. We investigated the syringe-like blood-feeding appendage, the stylet, and discovered that sexually dimorphic stylet neurons taste blood. Using pan-neuronal calcium imaging, we found that blood is detected by four functionally distinct stylet neuron classes, each tuned to specific blood components associated with diverse taste qualities. Stylet neurons are insensitive to nectar-specific sugars and respond to glucose only in the presence of additional blood components. The distinction between blood and nectar is therefore encoded in specialized neurons at the very first level of sensory detection in mosquitoes. This innate ability to recognize blood is the basis of vector-borne disease transmission to millions of people worldwide. |
| Databáze: | OpenAIRE |
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