Time Sensitivity: A Parameter Reflecting Tumor Metabolic Kinetics by Variable Dual-Time F-18 FDG PET Imaging
| Autor: | Daniel Noujaim, Ching-yee Oliver Wong, Cheng-yi S. Cheng, Chih-Yung Chang, Hungsen F. Fu, Ishani Dalal, Wen-Sheng Huang, Conrad E. Nagle, Joseph A. Thie |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Blood Glucose Male Cancer Research Time Factors Standardized uptake value Fluorodeoxyglucose positron emission tomography Fluorodeoxyglucose F18 Metabolic kinetics Linear regression medicine Humans Radiology Nuclear Medicine and imaging Aged business.industry Time sensitivity Middle Aged F 18 fdg pet medicine.disease Primary tumor Oncology Head and Neck Neoplasms Positron-Emission Tomography Linear Models Female Radiopharmaceuticals Tomography X-Ray Computed Nuclear medicine business Algorithms Brain metastasis |
| Zdroj: | Molecular Imaging and Biology. 11:283-290 |
| ISSN: | 1860-2002 1536-1632 |
| DOI: | 10.1007/s11307-009-0206-3 |
| Popis: | The aim of this study was to define and investigate the time sensitivity of tumors by variable dual-time fluorodeoxyglucose positron emission tomography (FDG PET). Variable dual-time (t) protocol (P) FDG PET–computed tomography (CT) scans from 40 patients with pathologically proven head and neck tumors without brain metastasis were analyzed. The first protocol (P.I) consisted of 26 patients with early (E) and delayed (D) PET–CT obtained at 106 ± 15 and 135 ± 16 min after injection of 16.3 ± 1.9 mCi FDG. The second protocol (P.II) recruited 14 patients with E- and D-PET performed at 54 ± 13 and 151 ± 28 min after injection of 9.6 ± 1.7 mCi FDG. The maximum standardized uptake values (SUVs) were measured in the primary tumor (CA1) and the cerebellum (CBL). The time sensitivity (S) was defined as d{ln(SUV)}/d{ln(t)} and its value was obtained by linear regression of ln(D-SUV/E-SUV) vs ln(t D/t E). Patients with cerebellar variations greater than 30% in SUV between E- and D-PET was excluded from the analysis. Two patients from P.I were excluded due to wide cerebellar SUV variations. D-SUV were significantly higher than E-SUV in CA1 for both P.I (18.9 ± 6.9 vs 14.8 ± 5.6, p |
| Databáze: | OpenAIRE |
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