Assessing Deep Retinal Capillary Ischemia in Paracentral Acute Middle Maculopathy by Optical Coherence Tomography Angiography
| Autor: | David Sarraf, Michael B. Gorin, Julia Nemiroff, Rishi R. Doshi, Ehsan Rahimy, Laura Kuehlewein, Irena Tsui, Alain Gaudric, Srinivas R. Sadda |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty genetic structures Adolescent Ischemia 03 medical and health sciences 0302 clinical medicine Retinal Diseases Ophthalmology Medicine Humans Fluorescein Angiography Child Scotoma Aged Retrospective Studies Aged 80 and over Plexus medicine.diagnostic_test business.industry Retinal Vessels Blood flow Anatomy Middle Aged Fluorescein angiography medicine.disease Capillaries 030104 developmental biology Angiography Acute Disease Chronic Disease 030221 ophthalmology & optometry Maculopathy Central retinal artery occlusion Female business Perfusion Tomography Optical Coherence Retinal Neurons |
| Zdroj: | American journal of ophthalmology. 162 |
| ISSN: | 1879-1891 |
| Popis: | Purpose To assess microvascular blood flow of the deep retinal capillary plexus in eyes with paracentral acute middle maculopathy using optical coherence tomography (OCT) angiography. Design Retrospective, multicenter observational case series. Methods Clinical and multimodal imaging findings from 8 patients with paracentral acute middle maculopathy were reviewed and analyzed. OCT angiography scans were analyzed and processed, and vessel density was calculated. Results Eight patients (7 male, 1 female, aged 9–82 years) were included. OCT angiography was obtained at either the acute (4 cases) or old stage (4 cases). Scans of the deep capillary plexus showed preservation of perfusion in acute lesions and capillary attenuation in old cases. Cases of central retinal artery occlusion showed marked loss of the deep capillary plexus. The mean vessel density of the superficial capillary plexus in normal fellow eyes was 12.8 ± 1.8 mm −1 vs 12.1 ± 1.9 mm −1 in eyes with paracentral acute middle maculopathy (reduction −6.0%, P = .08). The mean vessel density of the deep capillary plexus in normal fellow eyes was 17.5 ± 1.4 mm −1 vs 14.7 ± 3.5 mm −1 in eyes with paracentral acute middle maculopathy (reduction −19.4%, P = .04). This significant difference was representative of the eyes with old lesions. Conclusion Paracentral acute middle maculopathy lesions correspond to preservation of perfusion in focal acute lesions and to pruning of the plexus in old cases. Cases of central retinal artery occlusion demonstrate marked hypoperfusion of the deep capillary plexus. Our study further supports an ischemic pathogenesis of this retinal vasculopathy. |
| Databáze: | OpenAIRE |
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