Molecular mechanisms of postoperative atrial fibrillation in patients with obstructive sleep apnea
| Autor: | Raquel López‐Gálvez, José Miguel Rivera‐Caravaca, Darío Mandaglio‐Collados, Esteban Orenes‐Piñero, Álvaro Lahoz, Diana Hernández‐Romero, Carlos M. Martínez, Marina Carpes, José María Arribas, Sergio Cánovas, Gregory Y. H. Lip, Francisco Marín |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Interleukin-6
fibrosis Pilot Projects Sleep Apnea Obstructive/complications post-operative atrial fibrillacion Biochemistry connexins MicroRNAs/genetics C-Reactive Protein Risk Factors von Willebrand Factor Genetics Humans atrial fibrillation Prospective Studies Molecular Biology Atrial Fibrillation/complications Biomarkers obstructive sleep apnea Biotechnology miRNA |
| Zdroj: | López-Gálvez, R, Rivera-Caravaca, J M, Mandaglio-Collados, D, Orenes-Piñero, E, Lahoz, Á, Hernández-Romero, D, Martínez, C M, Carpes, M, Arribas, J M, Cánovas, S, Lip, G Y H & Marín, F 2023, ' Molecular mechanisms of postoperative atrial fibrillation in patients with obstructive sleep apnea ', The FASEB Journal, vol. 37, no. 6, e22941 . https://doi.org/10.1096/fj.202201965RR |
| DOI: | 10.1096/fj.202201965RR |
| Popis: | Obstructive sleep apnea (OSA) promotes atrial remodeling and fibrosis, providing a substrate for atrial fibrillation (AF). Herein, we investigate the pathophysiological mechanisms of AF in association with OSA in a cohort of cardiac surgery patients. A prospective study including patients undergoing cardiac surgery. Biomarkers reflective of AF pathophysiology (interleukin [IL-6], C-reactive protein [CRP], von Willebrand factor [vWF], N-terminal pro-brain natriuretic peptide [NT-proBNP], high-sensitivity Troponin T [hs-TnT], and Galectin-3 [Gal-3]) was assessed by functional or immunological assays. miRNAs involved in AF were analyzed by reverse transcription-polymerase chain reaction (RT-PCR). Using atrial tissue samples, fibrosis was assessed by Masson's trichrome. Connexin 40 and 43 (Cx40; Cx43) were evaluated by immunolabeling. Fifty-six patients (15 with OSA and 41 non-OSA) were included in this hypothesis-generating pilot study. OSA group had a higher incidence of postoperative AF (POAF) (46.7% vs. 19.5%; p = .042), presented an increased risk of POAF (OR 3.61, 95% CI 1.01-12.92), and had significantly higher baseline levels of NT-proBNP (p = .044), vWF (p = .049), Gal-3 (p = .009), IL-6 (p = .002), and CRP (p = .003). This group presented lower levels of miR-21 and miR-208 (both p |
| Databáze: | OpenAIRE |
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