Genomic insights into chromatin reprogramming to totipotency in embryos
| Autor: | Sabrina Ladstätter, Kikuë Tachibana |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
animal structures
Reviews Embryonic Development Review Cell fate determination Epigenesis Genetic Histones 03 medical and health sciences Mice 0302 clinical medicine Histone code Animals Epigenetics skin and connective tissue diseases 030304 developmental biology 0303 health sciences Genome biology Gene Expression Regulation Developmental Cell Differentiation Cell Biology Epigenome DNA DNA Methylation Cellular Reprogramming Embryo Mammalian Chromatin Cell biology Histone Code Histone Germ Cells DNA methylation embryonic structures biology.protein sense organs Reprogramming 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| Popis: | Ladstätter and Tachibana discuss changes in DNA methylation, chromatin accessibility, and topological architecture occurring during the reprogramming to totipotency in the early embryo. The early embryo is the natural prototype for the acquisition of totipotency, which is the potential of a cell to produce a whole organism. Generation of a totipotent embryo involves chromatin reorganization and epigenetic reprogramming that alter DNA and histone modifications. Understanding embryonic chromatin architecture and how this is related to the epigenome and transcriptome will provide invaluable insights into cell fate decisions. Recently emerging low-input genomic assays allow the exploration of regulatory networks in the sparsely available mammalian embryo. Thus, the field of developmental biology is transitioning from microscopy to genome-wide chromatin descriptions. Ultimately, the prototype becomes a unique model for studying fundamental principles of development, epigenetic reprogramming, and cellular plasticity. In this review, we discuss chromatin reprogramming in the early mouse embryo, focusing on DNA methylation, chromatin accessibility, and higher-order chromatin structure. |
| Databáze: | OpenAIRE |
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